The Monarch has filmed a first-hand account concerning his journey with cancer, set to air as part of this year's Stand Up To Cancer initiative, run by Cancer Research UK and a television broadcaster.
Official sources said the King would reflect on his "path to recovery" as a individual battling cancer, in a recorded address on Friday evening at the evening slot.
The message, recorded at Clarence House two weeks ago, will emphasise the importance of cancer screening checks to help guarantee more people detect the disease at an initial point.
This will be a uncommon insight on the wellbeing of the King, who has been undergoing regular treatment since revealing his diagnosis in the start of 2024. Analysts suggest unlikely the King will specify his particular diagnosis.
The Stand Up To Cancer initiative each year raises funds for scientific studies and treatment and encourages people to get check-ups to improve the chances of an early diagnosis.
The King's candid approach about his illness, and living with cancer, has been designed to promote education and to persuade more people to get tested - and this will be escalated with this unusual royal involvement.
Up until now the King's main approach to his cancer has been to continue his schedule, maintaining a busy schedule alongside his regular rounds of care, and he appears not to have desired to be characterised by his illness.
The past twelve months has seen the King, 77, undertaking several international tours, including to Italy and Canada, and welcoming the largest volume of foreign dignitaries to the UK for a generation, which included the German president in recent days.
This Friday's Stand Up to Cancer show on Channel 4, presented by presenters including several TV personalities, will urge people not to be scared of getting preventative tests.
All three have been affected by cancer - McCall said last month she had had an operation for breast cancer, while another presenter was diagnosed with the illness over a decade ago. Presenter Hills has previously discussed his father, who had one form of cancer and then later another illness.
The broadcast will appeal to the estimated 9m people in the UK who charities says are not compliant with national health programmes, with an digital tool to let people check if they are qualified for tests for key health indicators.
In an effort to explain cancer checks and show the importance of timely identification there will be a live broadcast from cancer clinics at two Cambridge hospitals in Cambridge.
"I want to take the fear from preventative tests and show everyone that they are not on their own in this," commented a presenter.
At present in the UK, there are a number of NHS cancer screening programmes - for specific cancers - available to eligible individuals.
A emerging preventative initiative is also being slowly rolled out for anyone at increased risk of contracting the illness, primarily aimed at people in a specific age bracket, who are smokers or were former smokers.
Men may enquire about prostate screenings, but there is not a universal scheme operational.
The Stand Up to Cancer project, which has collected a significant sum for many years, is financing dozens of research studies involving 13,000 patients.
The Monarch, in a statement for guests at a reception for support groups in the spring, had spoken of recognising the "intimidating and at times frightening experience" for cancer sufferers and their support networks.
But he stated his experience of managing cancer had revealed that "the most difficult times of disease can be illuminated by the greatest compassion," as he thanked those who supported those receiving treatment.
Royal representatives has not revealed the specific type of cancer the King has, or the therapies he has undergone. The King's cancer was identified after he had had a medical treatment.
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